Immunotherapy is the Next Option

When antihistamines and intranasal steroids (“INS”) repeatedly fail to relieve seasonal allergy symptoms, the next option is usually to see a specialist (Allergist) to learn more about what specific allergens are aggravating us and potentially find a solution.  Allergists can do skin testing and prescribe allergy immunotherapy in the form of shots or sublingual drops. When taken regularly, this type of immunotherapy encourages your body to produce antibodies for whatever specific allergens that were problematic to you in your tests. Thus, you become less reactive and more “immune” to those particular irritants. Allergy immunotherapy can also be effective against some molds, because mold is an antigen, allergen, and living microorganism.

The process of allergy immunotherapy involves injecting the body with small amounts of the specific elements you are allergic to in order to provoke your body to produce antibodies.  It takes several weeks for your body to develop an initial batch of antibodies.   These antibodies attack allergens.  Once the allergens are identified and remembered, the body will produce adequate antibodies sufficient to buoy the body’s resistance.

About the Immune System

The immune system is the human body’s defense against an almost infinite number of foreign elements in the world that can make us sick.  It is composed of many biological structures and processes that distinguish, trap, kill, and remove foreign invaders from our bodies. Simplistically, we have three lines of defense:

First Line Defense

  • Our skin is the first barrier to pathogens. On the skin and our various orifices, there are secretions that restrict and expel invaders (tears, nasal excretion, sneezing and coughing, sweating, etc.).
  • Mucous membranes and microscopic hairs also protect the external entry points for pathogens.
  • Pathogens that are ingested meet and are destroyed by potent gastric acids and beneficial bacteria in the stomach.

Second Line Defense- Innate Immunity (Non-specific)

  • These are non-specific cellular responses to foreign antigens.
  • Eosinophils and T cells immediately mobilize to attack the pathogens.
  • Our inflammatory responses increase capillary permeability leading to reactions, like swelling, rashes, itching, etc., in addition to recruiting proteins and cells to address and regulate immune activity.
  • Fevers increase body temperature and activate proteins that suppress microbial growth.

Third Line- Adaptive or Humoral Immunity (Specific)

  • The body produces antibodies that attack specific antigens in our bodies.
  • Our bodies remember specific antigens to target and mass produce antibodies against them anytime those antigens are identified.

I have provided a more detailed and scientific description in an article published last year entitled “War of The Worlds.”

Allergy Immunotherapy

Allergy shots employ the third line of defense by proactively inducing your body to produce antibodies to specific antigens you are allergic to. Skin tests are performed to determine which things create a reaction. Initially, the physician exposes your skin to a large panel of different allergens to test for allergic reactions.

After that, you will return to see your physician 1-2 times a week to receive a shot of increasing amounts of allergens in the upper arm. The first time you are given a shot, you will have to remain at the doctor’s

office for approximately 30 minutes in case of any serious side effects.  In that event, an emergency shot will be given to counter the attack.  Severe allergic reactions require epinephrine.

An EpiPen must be carried with patients at all times.

Sublingual Immunotherapy (“SLIT”), while not yet approved in the US (except for pills for ragweed and pollen), is commonly used in Europe and other parts of the world.

Following allergen testing, a prepared mixture of allergens is administered under

 the tongue by the patient.  That particular area is extremely vascular and enables quick and optimal bloodstream absorption without having to go through the digestive system, like a pill or capsule.
SLIT therapy is also significantly more convenient than injections as it does not require frequent doctor visits or shots.  (It is important to note that it can take numerous weeks for the antibodies to be produced and effective against allergens.)

Sinus Defense

Sinus Defense was developed by Dr. Dennis after decades of treating patients with chronic sinusitis, allergies, and mold illness. Sinus Defense capitalizes on elements from both innate and adaptive immune responses to immediately address foreign invaders in our systems, specifically, molds, seasonal allergens, and co-viruses often activated by environmental illness. Practically, the sublingual spray has convenience and ease-of-use which leads to compliance advantages over other immunotherapies.

The product utilizes transfer factor, a large molecule derived from colostrum.  Colostrum is the vehicle that transfers the blueprint of a mother’s immunity to her child via breast milk.  Scientists have since proven that transfer factor can transfer immunity from one individual to another. Transfer factor has also been shown to be identical between species and can thus be used to transfer immunity between species (ex. bovine to human).

As opposed to the body generating antibodies specific to an antigen over several weeks or months, Sinus Defense is designed to identify and tag a significant number of antigens and allergens immediately.  When this occurs, our bodies can employ innate immunity (cell-mediated immunity) to kill and remove the foreign antigens via T cells and macrophages.  In the end, patients experience prompt relief, because their bodies are effectively capitalizing on and harnessing their innate immunity. It is just a more efficient way of addressing allergens, like mold, that you are always going to encounter, even when you are living in a clean environment.

Comparing Costs

Allergy Shots

Allergy shots are not prohibitively priced if you have insurance and a decent copay; however, you must consider your time and opportunity costs. You must also expect to stay at the office at least 30 minutes after taking the shots to be sure you do not have a serious allergic reaction, like shortness of breath or anaphylaxis.

Sublingual drops

Sublingual Allergy Immunotherapy (SLIT) can be more expensive than other medicines.  Since shots or drops must be prepared custom for patients, cost can be up to $100 per month, per antigen.  The total cost can approach thousands per 6-month period. Single allergens may be less.  You must take total cost into consideration, or at least whether they will be paid out of pocket if you haven’t met your deductible.

Sinus Defense

You can purchase Sinus Defense for $79.99 per bottle which lasts 30-60 days.  If you ask for your physician to write a prescription for Sinus Defense, you can use your Health Savings Account (“HSA”) to pay for it.  Physicians who use Sinus Defense regularly report it targets a very broad range of allergens, antigens, molds and some viruses.  In addition, there is antidotal evidence that other invader-caused ailments have lessened due to Sinus Defense use.  For example, patients suffering from genital herpes have reported fewer or the absence of outbreaks while using Sinus Defense.  This seems to be a direct improvement over the medicine of choice, Valtrex; however, this has not been scientifically substantiated at this time.

Maximum Therapy Bundle for Mold Allergies

In order to optimize your body’s immune system function against allergies, MicroBalance has bundled three products that work best when used together. Sinus Defense’s potency can be enhanced significantly with the addition of BetaMax 500.  BetaMax is beta glucan which increases lymphocyte and macrophage production–the cells in your body that destroy infection and remove debris and toxins. Then the sublingual Celltropin spray can be added to promote cellular recovery and healing, especially helpful for people who have been compromised by mold. Its formula provides pituitary, circulatory and DNA support to speed cellular repair and turnover when the immune system is stressed and attacked by environmental toxins.

Immunotherapy-New Developments

During the past couple of decades, including now, immunotherapy has been at the forefront of medical and pharmaceutical science for good reason.

Several of the top-selling drugs for many serious diseases have capitalized on the immune system to either target immune system elements or to keep it from attacking our own bodies as seen with autoimmune diseases (Rheumatoid arthritis, Crohn’s disease, MS).  Today, cancer immunotherapies populate the headlines as significantly better prognoses and survival rates have been met with great enthusiasm as the future of medicine.





About the Author:

Cesar Collado is a former pharmaceutical R&D executive, venture capitalist, and seasoned strategy consultant in biotechnology and technology industries in general. He currently works as an advisor to multiple technology start-ups and advises several companies that provide healthcare and other services for environmental illness. Read More


  1. Name (required) April 17, 2018 at 12:10 pm - Reply

    I was on LDA for 2 years and it did help, but once my doctor joined in with a hospital is was no longer allowed to give them :(

  2. amy April 10, 2018 at 6:08 pm - Reply

    Hello, Please research LDA ( low dose allergy ) treatment for allergies and share with your readers.
    You can look at it on Dr. Schrader’s website and others.

    • Cesar Collado April 12, 2018 at 9:03 pm - Reply

      Thank you for your question.

      Low dose allergy Therapy LDA (first discovered in 1967) is a treatment that is used by some physicians, but it is not yet mainstream. From what I was able to gather and discussion with physicians is that it is effective with allergies. The enzyme “beta glucuronidase”, is added to minute amounts of allergens. There are two true benefits to LDA. 1) Shots are taken at they physicians office every 2-3 months. 2) It appears to have some effect on a broader population of allergens including some chemicals such as perfume and chemical off-gassing of household furnishings. Patients with Multiple Chemical Sensitivity can find some relief. These are patients that have reached their toxic load and become very sensitive to many VOCs. There are several other related disease states that it may work on as well. Data is very limited on these. Most of this data is limited to the physicians treating the patients and the specific mixtures they use.

      While it appears to be based on the same theory of regular allergy immunotherapy, it’s mechanism of action is different. It increases T regulator cells. The T cells address irregular cellular responses to other immune response cells. Simply put, this stops the allergic or adverse response. Regular allergy immunotherapy introduces larger amounts of antigens that trigger the immune system to produce antibodies that fight the specific allergens.

      The literature is limited and it appears to me that a much smaller population of physicians, many of them produce their own “recipe” for the therapy. This heterogeneity makes it hard to have broad scientific study across the treatment as a whole.

      The downside is that the shot comes with some pain because it is inter-dermal. Some localized swelling occurs. “Feels like a bee sting” cited one physician I spoke to who takes LDA. The physician may also prescribe some dietary restrictions, IV “booster” nutrition, and other instructions to avoid interference with the therapy.

      This is a high level look. It warrants more research. If you desire to try LDA, my suggestion would be to see a physician who has significant experience treating environmental illness or allergies with LDA. It is there own experience using the product that will drive their confidence in the treatment.

      Again, I am not a physician so you should also take this question to your physician to get their response and experience.

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