Chronic Sinusitis and Mold Exposure can Cause Fatigue due to Hormone System Imbalance

By Cesar Collado

Almost all patients with chronic illnesses suffer from some form of extreme fatigue.  In fact, severe fatigue is one of the most common symptoms mentioned by patients who suffer from a history of mold exposure and chronic sinusitis.  A group of these patients was studied by Dr. Dennis and colleagues to determine if there was a direct, causal relationship between mold exposure and deficiency in growth hormone. In addition to the chronic fatigue, their study observed more than half of the patients studied had a growth hormone deficiency measured by an insulin tolerance test (“ITT”). Insulin and growth hormone play antagonist roles against one another.  When one is elevated, the other will be low.  Extrapolating from the results of these tests, one can estimate that 4-5 million patients in the US could be suffering from chronic fatigue due to growth hormone deficiency from mold exposure.

A definitive diagnosis of Growth Hormone Deficiency (“GHD”) was not made in these cases.  A Growth Hormone Deficiency diagnosis (“Pituitary Dwarfism”) is a rare disorder, mostly in children, characterized by the inadequate secretion of growth hormone from the pituitary gland. Replacement treatment can cost $14-30,000 per year, and it is regulated and reimbursed tightly. The diagnostics used here determined the drop and depletion/disruption of normal secretions and levels of growth hormone. These patients that were tested were not previously diagnosed with GHD. It is assumed that normal production of growth hormone stopped or decreased, due to toxic disruption. These patients have a hormone disruption, where their body has told growth hormone to “turn off” as a protective mechanism.  There have been similar findings with patients that are not typical patients for human growth hormone replacement such as in chronic fibromyalgia and pain; however, treatment and costs remain the same as for ‘rare diseases’ and may not be reimbursed or covered by many insurances.

Drs. Dennis and Robertson’s findings showed that chronic sinusitis patients suffering from extreme fatigue as measured by a subjective energy scale of less than 5 out of 10 (10 meaning the ability to walk 5 miles), 53% of these patients suffered from growth hormone deficiency. The research found that almost all patients studied had normal resting levels of IGF1. It is for this reason that the physicians performed an ITT for confirmation of growth hormone deficiency.  These findings were published in a Toxicology Journal, entitled “Fungal Exposure Endocrinopathy in Sinusitis with Growth Hormone Deficiency.  Dennis-Roberson Syndrome”.1

Below is an overview of the patients studied:

The researchers concluded that fungal exposure is directly related to hormone deficiency. This finding likely represents a major cause of growth hormone deficiency, potentially affecting 4.8 M, resulting in chronic fatigue. This figure is overwhelming, given the comparison to the approximately 60,000 patients treated with HGH of all other causes of GHD. These GHD patients are mostly children with few adult-onset GHD patients, due to serious pituitary issues.  Again, treatment for these patients with Human Growth Hormone replacement therapy is not common or practical and overly expensive at a cost of costs $14-30,000 per year.  HGH is tightly regulated due to and challenging to get reimbursed without a definitive diagnosis.

The Impact of Pituitary Damage

The pituitary gland is called the “Master Gland” as it is responsible for numerous hormone systems in the body.  It is located adjacent to the sphenoid sinuses. It controls numerous hormonal systems.

  • Growth hormone, which regulates growth, metabolism and body composition
  • Adrenocorticotropic hormone, which stimulates the adrenal glands to secrete steroid hormones, principally cortisol
  • Gonadotrophins also known as luteinising hormone and follicle stimulating hormone, They act on the ovaries or testes to stimulate sex hormone production, and egg and sperm maturity
  • Prolactin, which stimulates milk production
  • Thyroid stimulating hormone, which stimulates the thyroid gland to secrete thyroid hormones.
  • Anti-diuretic hormone, which controls water balance and blood pressure
  • Oxytocin, which stimulates uterine contractions during labor and milk secretion during breastfeeding.
  • Melanocyte-stimulating hormone, which acts on cells in the skin to stimulate the production of melanin.

One of the reasons for growth hormone deficiency due to mold exposure is that there is a fungal receptor on the cell wall in the anterior pituitary that bind to fungal cells and activate the immune system. The macrophages sent to remove the antigen can destroy the fungus and tissues of the pituitary.

Inflammatory responses due to sinusitis fungal infection can have an impact on the adjacent pituitary tissue and function.  In addition, mycotoxins reaching the inner sinuses adjacent to the same sphenoid sinuses and the brain can permanently damage nerves and cause neurological symptoms if they reach the blood-brain barrier.


Fungal Treatment is Essential

Fungal sinusitis is the result of fungal infection and exposure to a source of mold.  In addition to following the doctor’s treatment plan and prescribed medicine, the patient must address the source of physical mold in their homes and sinuses or they may not be able to get better:

  1. Removal from the source of mold or fungus. This includes moving to a safe environment and identifying and remediating the source of moisture and mold in the living environment.
  2. Rinsing of the sinuses with a nasal wash system with saline with antifungal properties such as CitriDrops Dietary Supplement to remove mold spores and infected mucous.
  3. Removal of sugars and refined carbohydrates from the diet. Mold and Candida have a sugar receptor on the cell wall. When sugar binds to it, it morphs the physical shape of the cell organism into an invasive hyphae form.  These resilient hyphae are like microscopic roots that can grow up to 3 feet long and can penetrate tissues causing inflammation, tissue destruction, and is more difficult to eradicate.

Addressing the Growth Hormone Deficiency and Cellular Healing: 

In addition to addressing the fungal source in the body and the air, the body’s natural healing system needs to repair the body itself.  Celltropin is a homeopathic remedy that promotes cellular healing and reproduction. Administration of 3-4 sublingual sprays taken 2-3 times a day to promote pituitary healing, cellular production, and will naturally increase growth hormone levels. Patients have reported increased energy and improved sleep.

Celltropin Ingredients include:

  • Pituitary Extract is used to supplement individuals who wish to boost hormonal functions. It is taken to promote cellular growth.  In fact, it is commonly used in laboratories to culture and grow human cells for medical research.
  • Astragalus Root has been used in traditional Chinese medicine for centuries. The antioxidant effects inhibit free radical production. It impacts Telomeres, regions on the end of chromosomes that play a role in cellular senescence or biological aging. As you get older, they shorten. Astragalus decreases the shortening of the Telomeres.
  • Arginine is an essential amino acid that plays an important role in cell division, wound healing, removing ammonia from the body, immune function, and the release of hormones. It is also a precursor for the synthesis of nitric oxide, which is important in the regulation of blood pressure.

Boosting Your Immune System

Sinus Defense is a sublingual spray formulation of transfer factor.

Transfer factor is the immune mechanism of transferring a mother’s immunity to her child.  It has been demonstrated to be effective in transferring immunity between species as well.  Sinus defense is programmed to identify and biologically adhere to mold antigens.  This allows the bodies immediate cell-mediated immunity system to destroy the tagged antigens using our natural T cells.


If chronic and extreme fatigue is one of your primary symptoms due to mold exposure, Drs. Dennis and Roberson’s findings suggest growth hormone deficiency may be a consideration.  If this is the case, it is likely that your immune system is reacting, and inflammation can impact both the duration and severity of your illness.  Utilizing transfer factor and supporting the pituitary utilizing these homeopathic remedies is a cost-effective way to determine if your condition could improve sooner.  It is likely to be more cost effective than going to multiple physicians using laboratory diagnostics.

1 Dennis, Robertson,, Toxicology and Industrial Health 25 (9-10) 669-680, 2009




About the Author:

Cesar Collado is a former pharmaceutical R&D executive, venture capitalist, and seasoned strategy consultant in biotechnology and technology industries in general. He currently works as an advisor to multiple technology start-ups and advises several companies that provide healthcare and other services for environmental illness. Read More


  1. Start Here: My Mold Toxicity Treatment Key - Mold Free Living July 4, 2019 at 1:44 am - Reply

    […] data showing that growth hormone production is compromised in patients with mold toxicity. (HERE is link to an article on mold toxins, chronic fatigue, and growth hormone depletion.) A good […]

  2. Janeen November 18, 2018 at 7:08 am - Reply

    I have no place else to live besides here. I suspect mold spores due to a furnace repair done wrong and a cracked heat exchanger letting a musty basement into my living space. I have 4 chihuahuas so selling and renting isn’t an option

  3. holli August 2, 2018 at 6:52 pm - Reply

    I have been diagnosed with a pituitary tumor or cyst ( yet to be determined) have very low hormones , recent hashimotos diagnosis. systemic involvement heart and lungs urticaria vasculitis and delayed cold urticaria. tremendous hair loss , weight gain, depression, anxiety, chronic fatigue , all over inflammation., I discovered i was living in mold last July .. moved out last september but have gone down hill since., I believe mostly because it took so long to discover all these conditions i was dealing with even though i expressed my symptoms to every doctor i saw . my question is do you think the pituitary growth is related to the exposure? and could be the cause of all my symptoms?

    side note also have discovered EBV reactivation and high strep antibodies

    • Cesar Collado August 2, 2018 at 11:23 pm - Reply

      Hi Holli,

      I’m very sorry for your situation. I am not a physician so I cannot give medical advice; however, to answer your question, mold could be the cause. It is important that you see the right physicians to address your hormone levels, whether you are immune suppressed, and to balance your nutrition to help your body detox if there are mycotoxins in your system. You may also want to see an ENT for a CT scan. Since mold enters through the nose to sinuses, the highest concentrations of mycotoxins can be in the nasal mucosa.

      If your pituitary is damaged, that could account for a hormonal imbalance that could be responsible for the chronic fatigue. The rest of these symptoms often accompany the chronic fatigue. I think you have to start with a physician who treats environmental illness. It is important that if your environment is what is making you sick, go get to a safe place.An environmental physician will address helping your body remove what is making you sick. Adding medicines to an environmental condition will unlikely correct the cause.

  4. Susan O'Connor July 20, 2018 at 7:31 pm - Reply

    Excellent article once again!! Thank you.
    Can u speak to the NO/ONO cycle that could cause an unfavorable reaction w/ some patients that might use this product?

    • Cesar Collado July 23, 2018 at 4:56 am - Reply

      Thank you! I will add this to my research. I looked it up. It is a very complicated process ; but, it is an excellent research topic for a post!

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